Self microemulsifying particles of loratadine for improved oral bioavailability: preparation, characterization and in vivo evaluation

The objective was to study the phase behavior of different formulations, to identify the micro emulsion area and to prepare solid SMEDDS particles (SSMED) of loratadine (LOR) for improving oral bioavailability (BA). Formulations were prepared with either Lauroglycol 90 or Peceol as oils, Solutol HS15 as surfactant and Transcutol P as co-surfactant. Then water titrations were done to know the phase behavior to identify microemulsion zone. The...