RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity
Abstract
Mitochondria act as a platform for antiviral innate immunity, and the immune system depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) signaling pathway via an adaptor molecule, mitochondrial antiviral signaling. We report that RLR-mediated antiviral innate immunity requires oxidative phosphorylation (OXPHOS) activity, a prominent physiologic function of mitochondria. Cells lacking mitochondrial DNA or...
Paper Details
Title
RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity
Published Date
Jul 14, 2017
Journal
Volume
7
Issue
1
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