Genetic adaptation to historical pathogen burdens
Abstract
Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden...
Paper Details
Title
Genetic adaptation to historical pathogen burdens
Published Date
Oct 1, 2017
Volume
54
Pages
299 - 307
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Notes
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