Simple Model of the Effect of Solution Conditions on the Nucleation of Amyloid Fibrils

It is well known that peptide and protein fibrillation is strongly affected by the solution conditions, but a fundamental understanding of how amyloid fibril nucleation depends on solution pH, salt concentration, and solvent is absent. Here, we use expressions from Debye–Hückel theory to describe the interactions between charged amino acids in combination with our recently developed nonstandard nucleation theory to predict the concentration...