Health effects of overweight and obesity in 195 countries over 25 years

Published on Jul 6, 2017in The New England Journal of Medicine70.67
· DOI :10.1056/NEJMoa1614362
Ashkan Afshin30
Estimated H-index: 30
(UW: University of Washington),
Mohammad H. Forouzanfar56
Estimated H-index: 56
(UW: University of Washington)
+ 150 AuthorsChristopher Margono150
Estimated H-index: 150
BACKGROUND Although the rising pandemic of obesity has received major attention in many countries, the effects of this attention on trends and the disease burden of obesity remain uncertain. METHOD ...
  • References (22)
  • Citations (672)
Published on Dec 1, 2016in Population Health Metrics2.95
Marie Ng27
Estimated H-index: 27
Patrick Liu8
Estimated H-index: 8
+ 1 AuthorsChristopher Margono150
Estimated H-index: 150
Background Understanding trends in the distribution of body mass index (BMI) is a critical aspect of monitoring the global overweight and obesity epidemic. Conventional population health metrics often only focus on estimating and reporting the mean BMI and the prevalence of overweight and obesity, which do not fully characterize the distribution of BMI. In this study, we propose a novel method which allows for the estimation of the entire distribution.
Published on Aug 25, 2016in The New England Journal of Medicine70.67
Béatrice Lauby-Secretan14
Estimated H-index: 14
Chiara Scoccianti17
Estimated H-index: 17
+ 3 AuthorsKurt Straif60
Estimated H-index: 60
The International Agency for Research on Cancer convened a workshop on the relationship between body fatness and cancer, from which an IARC handbook on the topic will appear. An executive summary of the evidence is presented.
Published on Aug 1, 2016in The Lancet59.10
Emanuele Di Angelantonio54
Estimated H-index: 54
Shilpa N Bhupathiraju22
Estimated H-index: 22
(UoB: University of Bristol)
+ 58 AuthorsGrace Joshy14
Estimated H-index: 14
Summary Background Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant data meta-analyses of prospective studies of body-mass index (BMI), limiting confounding and reverse causality by restricting analyses to never-smokers and excluding pre-existing disease and the first 5 years of follow-up. Methods Of 10 625 411 participants in Asia, Australia and New Zealand, Europe, and North America from 23...
Published on Jan 1, 2016in The Lancet59.10
Mariachiara Di Cesare15
Estimated H-index: 15
(Imperial College London),
James Bentham11
Estimated H-index: 11
(Imperial College London)
+ 737 AuthorsJulio Zuñiga Cisneros6
Estimated H-index: 6
Background Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its ...
Published on Jun 1, 2015in The Lancet59.10
Corinna Hawkes40
Estimated H-index: 40
Trenton G. Smith8
Estimated H-index: 8
(University of Otago)
+ 5 AuthorsJuliana Kain B24
Estimated H-index: 24
(University of Chile)
Summary Prevention of obesity requires policies that work. In this Series paper, we propose a new way to understand how food policies could be made to work more effectively for obesity prevention. Our approach draws on evidence from a range of disciplines (psychology, economics, and public health nutrition) to develop a theory of change to understand how food policies work. We focus on one of the key determinants of obesity: diet. The evidence we review suggests that the interaction between huma...
Published on Jun 1, 2015in The Lancet59.10
Christina A. Roberto27
Estimated H-index: 27
(Harvard University),
Boydoyd Swinburn68
Estimated H-index: 68
(University of Auckland)
+ 6 AuthorsKelly D. Brownell93
Estimated H-index: 93
(Duke University)
Summary Despite isolated areas of improvement, no country to date has reversed its obesity epidemic. Governments, together with a broad range of stakeholders, need to act urgently to decrease the prevalence of obesity. In this Series paper, we review several regulatory and non-regulatory actions taken around the world to address obesity and discuss some of the reasons for the scarce and fitful progress. Additionally, we preview the papers in this Lancet Series, which each identify high-priority ...
Published on Jan 8, 2014in JAMA51.27
Marie Ng27
Estimated H-index: 27
(UW: University of Washington),
Michael K. Freeman14
Estimated H-index: 14
(UW: University of Washington)
+ 9 AuthorsAlan D. Lopez122
Estimated H-index: 122
(University of Melbourne)
Importance Tobacco is a leading global disease risk factor. Understanding national trends in prevalence and consumption is critical for prioritizing action and evaluating tobacco control progress. Objective To estimate the prevalence of daily smoking by age and sex and the number of cigarettes per smoker per day for 187 countries from 1980 to 2012. Design Nationally representative sources that measured tobacco use (n = 2102 country-years of data) were systematically identified. Survey data that ...
Published on Jan 1, 2014in The Lancet59.10
Yuan Lu22
Estimated H-index: 22
Kaveh Hajifathalian13
Estimated H-index: 13
+ 3 AuthorsGoodarz Danaei42
Estimated H-index: 42
The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Eff ects)* Summary Background Body-mass index (BMI) and diabetes have increased worldwide, whereas global average blood pressure and cholesterol have decreased or remained unchanged in the past three decades. We quantifi ed how much of the eff ects of BMI on coronary heart disease and stroke are mediated through blood pressure, cholesterol, and glucose, and how much is independent of these factors. Metho...
Cited By672
Published on 2020in Journal of Surgical Research1.87
Andrew J. Weaver (Marshall University), Reagan Stafford (Marshall University)+ 2 AuthorsJuan Ramon Sanabria39
Estimated H-index: 39
Abstract Background Hepatic, pancreas, and biliary (HPB) cancers pose serious challenges to global health care systems. These malignancies demonstrate great geographical variations with shifting trends over time. The aim of the present study was to determine the recent trends in incidence, prevalence, and mortality of primary HPB malignancies to guide the further development of effective strategies for prevention, screening, and treatment. Methods The Global Burden of Disease (GBD) dataset 1990-...
Published on Dec 1, 2019in Scientific Reports4.01
Itziar Lamiquiz-Moneo5
Estimated H-index: 5
Rocío Mateo-Gallego15
Estimated H-index: 15
(University of Zaragoza)
+ 7 AuthorsAna Cenarro27
Estimated H-index: 27
The aim of our study was to investigate a large cohort of overweight subjects consuming a homogeneous diet to identify the genetic factors associated with weight loss that could be used as predictive markers in weight loss interventions. We retrospectively recruited subjects (N = 788) aged over 18 years with a Body Mass Index (BMI) between 25 and 40 kg/m2 who were treated at our lipid unit for at least one year from 2008 to 2016, and we also recruited a control group (168 patients) with normal B...
Published on Dec 1, 2019in Appetite3.50
Audrey Cloutier-Bergeron1
Estimated H-index: 1
(Laval University),
Véronique Provencher19
Estimated H-index: 19
(Laval University)
+ 4 AuthorsCatherine Bégin13
Estimated H-index: 13
(Laval University)
Abstract Objective Health At Every Size® (HAES®) interventions have been increasingly recognized as a sustainable strategy in obesity management. Nevertheless, heterogeneity among obese individuals leads to challenges as it translates in mixed responses to treatment. In this context, our objective was to identify trajectories of responses to a non-diet intervention for adult overweight/obese women to highlight profiles of responders. Method Based on data from a multicentric quasi-experimental st...
Published on Dec 1, 2019in Nutrition & Metabolism3.60
Seon-Jeong Lee (KNU: Kyungpook National University), Su-Jung Cho7
Estimated H-index: 7
(KNU: Kyungpook National University)
+ 1 AuthorsMyung-Sook Choi46
Estimated H-index: 46
(KNU: Kyungpook National University)
Background Obesity increases the risk of metabolic dysfunction such as dyslipidemia, hypertension, and fatty liver. Physcion (PY) is an anthraquinone that reportedly has anti-inflammatory and anti-bacterial properties. However, few studies have addressed the effect of PY on high-fat diet-induced obesity in mice. The purpose of this study was to investigate the effects of PY on obesity.
Published on Apr 24, 2019in BMC Pediatrics1.98
Gengdong Chen (Southern Medical University), Huanchang Yan (Southern Medical University)+ 6 AuthorsZheqing Zhang (Southern Medical University)
Background Former evidence regarding reference values of abdominal fat percentage (AFP) and optimal anthropometric indicators in predicting abdominal obesity measured by dual-energy X-ray absorptiometry (DXA) scan in Chinese children were scarce.
Published on Dec 1, 2019in BMC Nephrology2.09
Marcello Tonelli96
Estimated H-index: 96
(U of C: University of Calgary),
Natalie Wiebe48
Estimated H-index: 48
(U of A: University of Alberta)
+ 4 AuthorsBrenda R. Hemmelgarn70
Estimated H-index: 70
(U of C: University of Calgary)
Despite the interrelationships between obesity, eGFR and albuminuria, few large studies examine how obesity modifies the association between these markers of kidney function and adverse clinical outcomes. We examined the joint associations between obesity, eGFR and albuminuria on four clinical outcomes (death, end-stage renal disease [ESRD], myocardial infarction [MI], and placement in a long-term care facility) using a population-based cohort with procedures from Alberta. Obesity was defined by...
Published on Dec 1, 2019in BMC Pregnancy and Childbirth2.41
Lei Liu1
Estimated H-index: 1
(Dalian Medical University),
Yanan Ma2
Estimated H-index: 2
(PRC: China Medical University (PRC))
+ 3 AuthorsDeliang Wen2
Estimated H-index: 2
(PRC: China Medical University (PRC))
Maternal body mass index is linked to short- and long-term unfavorable health outcomes both for child and mother. We conducted a systematic review and meta-analysis of population-based cohort studies to evaluate maternal BMI and the risk of harmful neonatal outcomes in China. Six databases identified 2454 articles; 46 met the inclusion criteria for this study. The dichotomous data on maternal BMI and harmful neonatal outcomes were extracted. Pooled statistics (odds ratios, ORs) were derived from...
Published on Mar 28, 2019in BMC Public Health2.57
Mattias Norrbäck3
Estimated H-index: 3
(KI: Karolinska Institutet),
Per Tynelius40
Estimated H-index: 40
(KI: Karolinska Institutet)
+ 1 AuthorsFinn Rasmussen11
Estimated H-index: 11
(Lund University)
Background People with mobility disability (MD) or obesity often have more health problems and are less able to participate in work than individuals without these conditions. This study investigated whether people burdened with MD and obesity have a greater risk of unemployment than people with either one (MD only or obesity only) or none of these conditions.
Published on Dec 1, 2019in Scientific Reports4.01
Xudong Feng1
Estimated H-index: 1
(Boston Children's Hospital),
Dongxian Guan1
Estimated H-index: 1
(Boston Children's Hospital)
+ 5 AuthorsUmut Ozcan21
Estimated H-index: 21
(Boston Children's Hospital)
Celastrol is a leptin-sensitizing agent with profound anti-obesity effects in diet-induced obese (DIO) mice. However, the genes and pathways that mediate celastrol-induced leptin sensitization have not been fully understood. By comparing the hypothalamic transcriptomes of celastrol and vehicle-treated DIO mice, we identified lipocalin-2 (Lcn2) as the gene most strongly upregulated by celastrol. LCN2 was previously suggested as an anorexigenic and anti-obesity agent. Celastrol increased LCN2 prot...
Published on Mar 4, 2019in BMC Public Health2.57
Hector Najera1
Estimated H-index: 1
(UoB: University of Bristol),
Shailen Nandy11
Estimated H-index: 11
(Cardiff University)
+ 1 AuthorsJaime Miranda4
Estimated H-index: 4
(UPCH: Cayetano Heredia University)
Rural-to-urban migration is associated with increased obesity, yet it remains unknown whether this association exist, and to what extent, with other types of internal migration. We conducted a secondary analysis of the Peruvian Demographic and Health Surveys (2005 to 2012) on data collected from women aged 15–49 years. Participants were classified as rural stayers, urban stayers, rural-to-urban migrants, intra-rural migrants, intra-urban migrants, and urban-to-rural migrants. Marginal effects fr...
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