3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis
Abstract
High-order chromatin structure plays important roles in gene expression regulation. Knowledge of the dynamics of 3D chromatin structures during mammalian embryo development remains limited. We report the 3D chromatin architecture of mouse gametes and early embryos using an optimized Hi-C method with low-cell samples. We find that mature oocytes at the metaphase II stage do not have topologically associated domains (TADs). In sperm,...
Paper Details
Title
3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis
Published Date
Jul 1, 2017
Journal
Volume
170
Issue
2
Pages
367 - 381.e20
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