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Dual loss of human POLQ and LIG4 abolishes random integration

Published on Dec 1, 2017in Nature Communications11.88
· DOI :10.1038/ncomms16112
Shinta Saito4
Estimated H-index: 4
,
Ryo Maeda4
Estimated H-index: 4
,
Noritaka Adachi29
Estimated H-index: 29
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Abstract
Homologous recombination mediated gene targeting is highly inefficient in human cells due to random integration events, Here the authors show that dual repression of polymerase θ and DNA ligase IV eliminate random integration events.
  • References (62)
  • Citations (16)
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References62
Newest
#1Alexander Zelensky (EUR: Erasmus University Rotterdam)H-Index: 4
#2Joost Schimmel (LEI: Leiden University)H-Index: 1
Last.Marcel Tijsterman (LEI: Leiden University)H-Index: 30
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#1Ragini Bhargava (City of Hope National Medical Center)H-Index: 3
#2David O. Onyango (City of Hope National Medical Center)H-Index: 2
Last.Jeremy M. Stark (City of Hope National Medical Center)H-Index: 26
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#1David W. Wyatt (UNC: University of North Carolina at Chapel Hill)H-Index: 4
#2Wanjuan Feng (UNC: University of North Carolina at Chapel Hill)H-Index: 2
Last.Dale A. Ramsden (UNC: University of North Carolina at Chapel Hill)H-Index: 34
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#1Sara Ahrabi (University of Oxford)H-Index: 3
#2Sovan Sarkar (University of Oxford)H-Index: 9
Last.Timothy C. Humphrey (University of Oxford)H-Index: 11
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#1Raphael Ceccaldi (Harvard University)H-Index: 12
#2Beatrice Rondinelli (Harvard University)H-Index: 4
Last.Alan D. D'Andrea (Harvard University)H-Index: 86
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#1Shinta Saito (YCU: Yokohama City University)H-Index: 4
#2Kiyoe Ura (Chiba University)H-Index: 20
Last.Noritaka Adachi (YCU: Yokohama City University)H-Index: 29
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#1Joseph A. Newman (SGC: Structural Genomics Consortium)H-Index: 14
#2C.D.O. Cooper (SGC: Structural Genomics Consortium)H-Index: 15
Last.O. Gileadi (SGC: Structural Genomics Consortium)H-Index: 35
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Cited By16
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#1Grégoire Cullot (French Institute of Health and Medical Research)
#2Julian Boutin (French Institute of Health and Medical Research)
Last.Véronique Guyonnet-Duperat (French Institute of Health and Medical Research)H-Index: 12
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#1Wanjuan Feng (UNC: University of North Carolina at Chapel Hill)H-Index: 2
#2Dennis A. Simpson (UNC: University of North Carolina at Chapel Hill)H-Index: 18
Last.Joel S. Parker (UNC: University of North Carolina at Chapel Hill)H-Index: 73
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#1Sandra Bosshard (UNIL: University of Lausanne)H-Index: 2
#2Pierre-Olivier Duroy (UNIL: University of Lausanne)
Last.Nicolas Mermod (UNIL: University of Lausanne)H-Index: 30
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#1Joost Schimmel (LUMC: Leiden University Medical Center)H-Index: 8
#2Robin van Schendel (LUMC: Leiden University Medical Center)H-Index: 9
Last.Marcel Tijsterman (LUMC: Leiden University Medical Center)H-Index: 30
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#1Aya Kurosawa (YCU: Yokohama City University)H-Index: 11
#2Hiroyuki Kuboshima (YCU: Yokohama City University)
Last.Noritaka Adachi (YCU: Yokohama City University)H-Index: 29
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#1Kostlend Mara (Université Paris-Saclay)H-Index: 1
#2Florence Charlot (Université Paris-Saclay)H-Index: 1
Last.Fabien Nogué (Université Paris-Saclay)H-Index: 19
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#1Alex Zelensky (EUR: Erasmus University Rotterdam)H-Index: 3
#2Mascha Schoonakker (EUR: Erasmus University Rotterdam)
Last.Roland Kanaar (EUR: Erasmus University Rotterdam)H-Index: 64
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#1Ragini Bhargava (Beckman Research Institute)H-Index: 1
#2Manbir Sandhu (Beckman Research Institute)H-Index: 2
Last.Jeremy M. Stark (Beckman Research Institute)H-Index: 9
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