Statistical Profiling of One Promiscuous Protein Binding Site: Illustrated by Urokinase Catalytic Domain
Abstract
While recent literature focuses on drug promiscuity, the characterization of promiscuous binding sites (ability to bind several ligands) remains to be explored. Here, we present a proteochemometric modeling approach to analyze diverse ligands and corresponding multiple binding sub-pockets associated with one promiscuous binding site to characterize protein-ligand recognition. We analyze both geometrical and physicochemical profile...
Paper Details
Title
Statistical Profiling of One Promiscuous Protein Binding Site: Illustrated by Urokinase Catalytic Domain
Published Date
Jul 11, 2017
Journal
Volume
36
Issue
10
Pages
1700040 - 1700040
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