The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Volume: 18, Issue: 10, Pages: 610 - 621
Published: Jul 5, 2017
Abstract
Recent insights into the roles of poly(ADP-ribose) polymerase 1 (PARP1) in mediating various DNA repair pathways, stabilizing DNA replication and modulating chromatin structure are being exploited clinically for the treatment of DNA repair-deficient cancers. Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases,...
Paper Details
Title
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Published Date
Jul 5, 2017
Volume
18
Issue
10
Pages
610 - 621
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