Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
Abstract
Misfolded endoplasmic reticulum proteins are retro-translocated through the membrane into the cytosol, where they are poly-ubiquitinated, extracted from the membrane, and degraded by the proteasome-a pathway termed endoplasmic reticulum-associated protein degradation (ERAD). Proteins with misfolded domains in the endoplasmic reticulum lumen or membrane are discarded through the ERAD-L and ERAD-M pathways, respectively. In Saccharomyces...
Paper Details
Title
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
Published Date
Jul 6, 2017
Journal
Volume
548
Issue
7667
Pages
352 - 355
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