Cell-cycle dynamics of chromosomal organization at single-cell resolution
Abstract
Chromosomes in proliferating metazoan cells undergo marked structural metamorphoses every cell cycle, alternating between highly condensed mitotic structures that facilitate chromosome segregation, and decondensed interphase structures that accommodate transcription, gene silencing and DNA replication. Here we use single-cell Hi-C (high-resolution chromosome conformation capture) analysis to study chromosome conformations in thousands of...
Paper Details
Title
Cell-cycle dynamics of chromosomal organization at single-cell resolution
Published Date
Jul 1, 2017
Journal
Volume
547
Issue
7661
Pages
61 - 67
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