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Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae)

Published on Dec 1, 2017in Parasites & Vectors3.03
· DOI :10.1186/s13071-017-2232-3
Kai Dang2
Estimated H-index: 2
(Universiti Sains Malaysia),
Stephen L. Doggett18
Estimated H-index: 18
(Westmead Hospital)
+ 1 AuthorsChow-Yang Lee19
Estimated H-index: 19
(Universiti Sains Malaysia)
Abstract
The worldwide resurgence of bed bugs [both Cimex lectularius L. and Cimex hemipterus (F.)] over the past two decades is believed in large part to be due to the development of insecticide resistance. The transcriptomic and genomic studies since 2010, as well as morphological, biochemical and behavioral studies, have helped insecticide resistance research on bed bugs. Multiple resistance mechanisms, including penetration resistance through thickening or remodelling of the cuticle, metabolic resistance by increased activities of detoxification enzymes (e.g. cytochrome P450 monooxygenases and esterases), and knockdown resistance by kdr mutations, have been experimentally identified as conferring insecticide resistance in bed bugs. Other candidate resistance mechanisms, including behavioral resistance, some types of physiological resistance (e.g. increasing activities of esterases by point mutations, glutathione S-transferase, target site insensitivity including altered AChEs, GABA receptor insensitivity and altered nAChRs), symbiont-mediated resistance and other potential, yet undiscovered mechanisms may exist. This article reviews recent studies of resistance mechanisms and the genes governing insecticide resistance, potential candidate resistance mechanisms, and methods of monitoring insecticide resistance in bed bugs. This article provides an insight into the knowledge essential for the development of both insecticide resistance management (IRM) and integrated pest management (IPM) strategies for successful bed bug management.
  • References (242)
  • Citations (29)
References242
Newest
#1Brittany E. Campbell (UF: University of Florida)H-Index: 2
#2Philip G. Koehler (UF: University of Florida)H-Index: 20
Last.R. W. Baldwin (UF: University of Florida)H-Index: 5
view all 4 authors...
#1David G. Lilly (USYD: University of Sydney)H-Index: 6
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Last.Stephen L. Doggett (USYD: University of Sydney)H-Index: 18
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#1Joshua B. Benoit (UC: University of Cincinnati)H-Index: 32
#2Zach N. Adelman (VT: Virginia Tech)H-Index: 25
Last.Stephen Richards (BCM: Baylor College of Medicine)H-Index: 49
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Cited By29
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#1Germana T Baraka (UDSM: University of Dar es Salaam)
#2Bruno A. Nyundo (UDSM: University of Dar es Salaam)H-Index: 1
Last.Eliningaya J. Kweka (Catholic University of Health and Allied Sciences)H-Index: 21
view all 5 authors...
#1Nicholas R Larson (ARS: Agricultural Research Service)
#2Aijun Zhang (ARS: Agricultural Research Service)H-Index: 23
Last.Mark F. Feldlaufer (ARS: Agricultural Research Service)H-Index: 24
view all 3 authors...
#1Keon Mook Seong (MSU: Michigan State University)H-Index: 6
#2Brad S. Coates (ARS: Agricultural Research Service)H-Index: 23
Last.Barry Robert Pittendrigh (MSU: Michigan State University)H-Index: 32
view all 3 authors...
View next paperInsecticide resistance in the bed bug: a factor in the pest's sudden resurgence?