Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells

Significance Here we show that GLAST, a major glutamate transporter in the cerebellar cortex, is essential for synaptic wrapping by Bergmann glia and synaptic wiring on Purkinje cells (PCs) by parallel fibers (PFs) and climbing fibers (CFs). Without GLAST, monoinnervation of PCs by single strong CFs and segregation of CF and PF territories along PC dendrites cannot develop normally or be maintained. PCs are frequently innervated by additional...