The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system
Abstract
The amyloid precursor protein (APP) is a type I transmembrane glycoprotein better known for its participation in the physiopathology of Alzheimer disease as the source of the beta amyloid fragment. However, the physiological functions of the full length protein and its proteolytic fragments have remained elusive. APP was first described as a cell-surface receptor; nevertheless, increasing evidence highlighted APP as a cell adhesion molecule. In...
Paper Details
Title
The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system
Published Date
Aug 15, 2017
Journal
Volume
143
Issue
1
Pages
11 - 29
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History