Abstract 136: Mineralocorticoid Receptor Activation In Macrophages Mediates High Fat/high Sucrose Induced Vascular Stiffness in Female Mice

Enhanced mineralocorticoid receptor (MR) activation promotes vascular dysfunction and remodeling. We studied the role of MR activation in perivascular adipose tissue (PVAT) macrophages in the development of high-fat/high-fructose diet (“Western Diet”, WD) induced vascular stiffness in female mice. Myeloid MR KO mice (MyMRKO) were fed a WD for 8 weeks (n=3). MyMRKO female mice (n=2) were infused with aldosterone (Aldo) for 3 weeks. Aortic...