The nucleation of protein crystals as a race against time with on- and off-pathways

Volume: 50, Issue: 4, Pages: 1056 - 1065
Published: Jun 30, 2017
Abstract
High supersaturation levels are a necessary but insufficient condition for the crystallization of purified proteins. Unlike most small molecules, proteins can take diverse aggregation pathways that make the outcome of crystallization assays quite unpredictable. Here, dynamic light scattering and optical microscopy were used to show that the nucleation of lysozyme crystals is preceded by an initial step of protein oligomerization and by the...
Paper Details
Title
The nucleation of protein crystals as a race against time with on- and off-pathways
Published Date
Jun 30, 2017
Volume
50
Issue
4
Pages
1056 - 1065
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