Burkea africana Hook (Caesalpiniaceae) ethanolic extract causes cell cycle arrest at M phase and induces caspase dependent apoptosis

Burkea africana Hook (Caesalpiniaceae) is a small to medium deciduous flat-topped tree up to 20 m tall that grows in Western and Southern Africa. Traditionally the bark decoction is used in treatment of fever, inflammation and cancer. Cytotoxic activity of the ethanolic extract was investigated using brine shrimp lethality assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using HeLa cells, cell cycle analysis,...