FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids

Volume: 45, Issue: 15, Pages: 8886 - 8900
Published: Jul 7, 2017
Abstract
The FANCJ DNA helicase is linked to hereditary breast and ovarian cancers as well as bone marrow failure disorder Fanconi anemia (FA). Although FANCJ has been implicated in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR), the molecular mechanism underlying the tumor suppressor functions of FANCJ remains obscure. Here, we demonstrate that FANCJ deficient human and hamster cells exhibit reduction in the overall gene...
Paper Details
Title
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids
Published Date
Jul 7, 2017
Volume
45
Issue
15
Pages
8886 - 8900
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