Recurrent and functional regulatory mutations in breast cancer
Abstract
Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By contrast, much less is known about cancer-causing mutations in non-coding regions. Here we perform deep sequencing in 360 primary breast cancers and develop computational methods to identify significantly mutated promoters. Clear signals are found in the promoters of three genes. FOXA1, a...
Paper Details
Title
Recurrent and functional regulatory mutations in breast cancer
Published Date
Jun 28, 2017
Journal
Volume
547
Issue
7661
Pages
55 - 60
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