Original paper
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
Abstract
Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands. Here we identify a new property of the human HP1α protein: the ability to form phase-separated droplets. While unmodified HP1α is soluble, either phosphorylation of its N-terminal extension or DNA binding...
Paper Details
Title
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
Published Date
Jun 21, 2017
Journal
Volume
547
Issue
7662
Pages
236 - 240
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Notes
History