Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism

Volume: 7, Issue: 1
Published: Jun 28, 2017
Abstract
Lethal systemic fungal infections of Candida species are increasingly common, especially in immune compromised patients. By in vitro screening of small molecule mimics of naturally occurring host defense peptides (HDP), we have identified several active antifungal molecules, which also exhibited potent activity in two mouse models of oral candidiasis. Here we show that one such compound, C4, exhibits a mechanism of action that is similar to the...
Paper Details
Title
Potent in vitro and in vivo antifungal activity of a small molecule host defense peptide mimic through a membrane-active mechanism
Published Date
Jun 28, 2017
Volume
7
Issue
1
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