LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
Abstract
The RNA binding protein, LARP1, has been proposed to function downstream of mTORC1 to regulate the translation of 5’TOP mRNAs such as those encoding ribosome proteins (RP). However, the roles of LARP1 in the translation of 5’TOP mRNAs are controversial and its regulatory roles in mTORC1-mediated translation remain unclear. Here we show that LARP1 is a direct substrate of mTORC1 and Akt/S6K1. Deep sequencing of LARP1-bound mRNAs reveal that...
Paper Details
Title
LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
Published Date
Jun 26, 2017
Journal
Volume
6
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