Heart rate lowering treatment leads to a reduction in vulnerable plaque features in atherosclerotic rabbits
Abstract
To investigate the effect of a heart rate (HR) lowering agent (Ivabradine) on features of atherosclerotic plaque vulnerability with magnetic resonance imaging (MRI), ultrasound imaging, and histology.Atherosclerosis was induced in the abdominal aorta of 19 rabbits. Nine rabbits were treated with Ivabradine (17 mg/kg/day) during the entire study period. At week 14, imaging was performed. Plaque size was quantified on contrast-enhanced T1-weighted...
Paper Details
Title
Heart rate lowering treatment leads to a reduction in vulnerable plaque features in atherosclerotic rabbits
Published Date
Jun 22, 2017
Journal
Volume
12
Issue
6
Pages
e0179024 - e0179024
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