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Kingiodendron pinnatum, a pharmacologically effective alternative for Saraca asoca in an Ayurvedic preparation, Asokarishta

Published on Jan 1, 2018in Journal of Traditional and Complementary Medicine
· DOI :10.1016/j.jtcme.2017.06.005
Adangam Purath Shahid1
Estimated H-index: 1
(Kerala Forest Research Institute),
Nanu Sasidharan2
Estimated H-index: 2
(Kerala Forest Research Institute)
+ 4 AuthorsThekkekara Devassy Babu4
Estimated H-index: 4
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Abstract
Abstract Saraca asoca (Fabaceae) is a prime ingredient in Asokarishta , a well-known Ayurvedic preparation for gynecological ailments. Due to scarcity, adulteration or substitution of related raw drugs is a common practice in its preparation. The bark of Kingiodendron pinnatum (Roxb. ex DC.) Harms, morphologically similar to S. asoca (Asoka) is a widely used substitute. The present study aimed to evaluate the pharmacological effectiveness of K. pinnatum as an alternative for S. asoca in Asokarishta by determining the inhibitory effect of estrogen induced uterus endometrial thickening in immature female rats. Arishta was prepared using S. asoca and with the substitute, K. pinnatum as per Ayurvedic Pharmacopeia. Uterus endometrial thickening was induced by the administration of estradiol (20 μg/kg b. wt, i.p) to 8-day-old rats for 5 alternate days. On day 16, following estradiol administration, the serum estrogen level was found elevated to 156.5 ± 8 pg/ml from the normal value 32.4 ± 5 pg/ml and consequently increased the thickness of uterus endometrium from 16.7 ± 1.4 to 75.2 ± 15.3 μm. Upon oral administration of 400 μl/kg b. wt Asokarishta (ASA) and Arishta made with K. pinnatum (AKP), the thickening was reduced to 42.5 ± 12.7 and 47.1 ± 10.5 μm and the estrogen level diminished to 102.6 ± 10 and 97.3 ± 8 pg/ml, respectively. Arishta also reduced the chronic/acute inflammations in mice and improved the antioxidant status of rats. No toxic symptom was observed in the animals by the treatment of Arishta . The study supports the use of K. pinnatum as an alternative to S. asoca in Asokarishta and gives a scientific validation for Asokarishta in gynecological ailments.
  • References (26)
  • Citations (1)
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References26
Newest
Published on Feb 1, 2017in Journal of Ethnopharmacology3.41
Pulok K. Mukherjee19
Estimated H-index: 19
(Jadavpur University),
Ranjit K. Harwansh8
Estimated H-index: 8
(Jadavpur University)
+ 6 AuthorsC.K. Katiyar1
Estimated H-index: 1
Abstract Ethnopharmacological relevance Ayurveda entails a scientific tradition of harmonious living and its origin can be traced from ancient knowledge in Rigveda and Atharvaveda . Ayurveda is a traditional healthcare system of Indian medicine since ancient times. Several Ayurvedic medicines have been exploiting for treatment and management of various diseases in human beings. The several drugs have been developed and practiced from Ayurveda since ancient time to modern practice as ‘tradition t...
Published on Feb 16, 2016in Natural Product Research2.00
Furkan Ahmad3
Estimated H-index: 3
(Central Institute of Medicinal and Aromatic Plants),
Laxminarain Misra15
Estimated H-index: 15
(Central Institute of Medicinal and Aromatic Plants)
+ 3 AuthorsRakesh Shukla32
Estimated H-index: 32
(Central Drug Research Institute)
Saraca asoca (Roxb.) de Wilde, a common tree of India, is popularly used in the Ayurvedic and modern herbal systems of medicine for genito-urinary problems of women. Considering the reported antimicrobial or anti-inflammatory effect of S. asoca bark against such infections, we studied the anti-inflammatory activity-guided isolation of active compounds from methanol extract. The methanol extract of bark has yielded 10 compounds out of which 3′-deoxyepicatechin-3-O-β-d-glucopyranoside (6) and 3′-d...
Published on Apr 1, 2015in Ancient Science of Life
Sandhya K Kamat1
Estimated H-index: 1
(King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College),
Prajakt J Barde1
Estimated H-index: 1
,
Sanket B Raut1
Estimated H-index: 1
(King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College)
Introduction: The objective of the study was to evaluate the estrogenic activity of four Indian medicinal plants Saraca indica ( Si ), Symplocos racemosa ( Sr ), Cyperus rotundus ( Cr ), Terminalia arjuna ( Ta ), a marketed preparation of Si ( Aśokārṣṭa ) and a combination of Si + Sr using an experimental model of estrogenicity. Materials and Methods: After approval of the institutional animal ethics committee, 22 day old female rats ( n = 54) were randomly allocated to 9 groups – Group 1 and Gr...
Sana Sheik1
Estimated H-index: 1
,
K. R. Chandrashekar4
Estimated H-index: 4
The leaf and stem extracts of two endemic plants, Kingiodendron pinnatum (DC.) Harms and Humboldtia brunonis Wallich of the family Fabaceae were subjected to phytochemical analysis, antimicrobial and antioxidant assay. Phytochemicals such as phenols, flavonoids, tannins, glycosides and terpenes were present in both plants. The antibacterial and antifungal activity assays were carried out using the disc diffusion method. Antioxidant activity was carried out using DPPH radical scavenging and reduc...
Pravin R Joshi1
Estimated H-index: 1
,
Bhupesh R Patel3
Estimated H-index: 3
,
Vinay J Shukla8
Estimated H-index: 8
Many Pratinidhi Dravyas in Ayurvedic classics are mentioned and certainly are based on a methodical approach, which involves many aspects. These principles on which Pratinidhis were decided are quoted nowhere; so both to understand the established Pratinidhis and to find new ones a rational approach is the need of the hour. This article is an effort in the direction to study this concept meticulously in light of modern techniques for its better understanding and application. As there are very fe...
Mansi B Modi1
Estimated H-index: 1
,
Shilpa B Donga2
Estimated H-index: 2
(Gujarat Ayurved University),
Laxmipriya Dei2
Estimated H-index: 2
(Gujarat Ayurved University)
Menopause is a gradual and natural transitional phase of adjustment between the active and inactive ovarian function and occupies several years of a women's life and involves biological and psychological changes adjustments. The present clinical trial was designed as per Ayurveda clinical trials protocol to evaluate the efficacy of Ashokarishta , Ashwagandha Churna and Praval Pishti in the management of menopausal syndrome. It was directed by Central Council for Research in Ayurvedic Sciences as...
Published on Jan 1, 2010
Sisodia Ss1
Estimated H-index: 1
Antioxidant potential of various extracts i.e. ethanolic, hydroalcoholic and acetone prepared by different extraction methods (Soxhlet extraction, Ultrasonication extraction and Microwave assisted extraction) of stem bark of Saraca asoca Roxb. De Wilde was studied by using DPPH (1,1, diphenyl-2 picryl hydrazyl) in-vitro model. The highest IC50 value 193.88 µg/ml were showed by hydroalcoholic (ethanol 60%) extract prepared by soxhlet extraction method. The acetone extract prepared by ultrasonicat...
Published on Feb 1, 2009in American Journal of Obstetrics and Gynecology6.12
Qian Zhang12
Estimated H-index: 12
(University of Texas MD Anderson Cancer Center),
Qi Shen3
Estimated H-index: 3
(University of Texas at Austin)
+ 10 AuthorsLei Deng6
Estimated H-index: 6
(University of Texas MD Anderson Cancer Center)
Objective We tested the hypothesis that the proliferative estrogen effect on the endometrium is enhanced in obese vs lean animals. Study Design Using Zucker fa/fa obese rats and lean control, we examined endometrial cell proliferation and the expression patterns of certain estrogen-regulated proproliferative and antiproliferative genes after short-term treatment with estradiol. Results No significant morphologic/histologic difference was seen between the obese rats and the lean rats. Estrogen-in...
Pankaj Pradhan4
Estimated H-index: 4
,
Lincy Joseph5
Estimated H-index: 5
+ 4 AuthorsA. Bajpai1
Estimated H-index: 1
Ashoka is the most ancient tree of India, generally known as a “ashok briksh”, botanist known as a Saraca asoca (Roxb.), De.wild or Saraca indica belonging family Caesalpinaceae . Medicinal herbs are moving from fringe to mainstream use with a great number of people seeking remedies and health approaches free from side effects caused by synthetic chemicals. Saraca asoca is reported to contain glycoside, flavanoids, tannins and saponins. It is used as spasmogenic, oxytocic, uterotonic, anti-bacte...
Cited By1
Newest
Published on Apr 1, 2019in Journal of Integrative Medicine
Deepak Kumar Semwal12
Estimated H-index: 12
,
Ashutosh Chauhan6
Estimated H-index: 6
+ 3 AuthorsAbhimanyu Kumar
Abstract The present market for herbal drugs is estimated about ₹40 billion, which is expected to increase by 16% in next 3–4 years. The current production of many Ayurvedic herbs is less than their market demand, which incentivizes adulteration in the Ayurvedic drug supply chain. The present work aims to highlight the most used Ayurvedic plants that have been listed in the International Union for Conservation of Nature’s “red list” of endangered or vulnerable plants. The future of Ayurvedic med...
Published on Mar 1, 2019in South African Journal of Botany1.50
S. Sekar (BDU: Bharathidasan University), A. Vinothkanna (BDU: Bharathidasan University)
Abstract Indian Ayurveda holds unique position among traditional medicines due to the possession of polyherbal Fermented Traditional Medicines (FTM) namely Arishta (fermented decoctions) and Asava (fermented infusions) which are self-generated microbial fermentations. There are many ancient scripts-based vernacular books on these medicines possessing scattered information. However, such FTM still remain elusive to the modern scientific curiosity. Hence, by applying the scientific principles, the...
View next paperEVALUATIOOF THE AALGESIC AD ATIPYRETIC ACTIOS OF THE SARACA ASOCA LEAVES IEXPERIMETAL AIMAL MODELS.