Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation

Volume: 10, Issue: 2, Pages: 548 - 552
Published: Jun 22, 2017
Abstract
We report the case of a patient with appendiceal adenocarcinoma with mucinous peritoneal carcinomatosis who was treated with trametinib upon identification of a <i>GNAS R201H</i> mutation by comprehensive genomic profiling. The molecular pathology of appendiceal neoplasms is reviewed, and the mechanistic basis underlying the clinical benefit as well as the subsequent course on trametinib that were observed in this patient are...
Paper Details
Title
Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation
Published Date
Jun 22, 2017
Volume
10
Issue
2
Pages
548 - 552
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