G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis.

Volume: 114, Issue: 27, Pages: 7077 - 7082
Published: Jul 3, 2017
Abstract
G9a is an epigenetic regulator that methylates H3K9, generally causing repression of gene expression, and participates in diverse cellular functions. G9a is genetically deregulated in a variety of tumor types and can silence tumor suppressor genes and, therefore, is important for carcinogenesis. Although hypoxia is recognized to be an adverse factor in tumor growth and metastasis, the role of G9a in regulating gene expression in hypoxia has not...
Paper Details
Title
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis.
Published Date
Jul 3, 2017
Volume
114
Issue
27
Pages
7077 - 7082
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