Antioxidant and antiapoptotic actions of selegiline protect against 3-NP-induced neurotoxicity in rats

Volume: 390, Issue: 9, Pages: 905 - 917
Published: Jun 23, 2017
Abstract
The present study was designed to investigate the neuroprotective effect of selegiline on 3-nitropropionic acid (3-NP)-induced neurotoxicity. Selegiline was intraperitoneally injected at doses 2.5, 5, and 10 mg/kg, 3 days prior to and continued daily, 30 min before 3-NP administration. 3-NP (20 mg/kg, i.p.) was administered for four consecutive days. 3-NP-treated rats exhibited PPI deficits, locomotor hypoactivity, increased striatal and...
Paper Details
Title
Antioxidant and antiapoptotic actions of selegiline protect against 3-NP-induced neurotoxicity in rats
Published Date
Jun 23, 2017
Volume
390
Issue
9
Pages
905 - 917
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