T cells from patients with Parkinson’s disease recognize α-synuclein peptides
Abstract
Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease...
Paper Details
Title
T cells from patients with Parkinson’s disease recognize α-synuclein peptides
Published Date
Jun 21, 2017
Journal
Volume
546
Issue
7660
Pages
656 - 661
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History