STRAP positively regulates TLR3-triggered signaling pathway
Abstract
Toll-like receptor (TLR) signaling drives the innate immune response by activating nuclear factor-κB (NF-κB) and interferon regulatory factor (IRF). We have previously shown that STRAP interacts with TAK1 and IKKα along with NF-κB subunit p65, leading to the activation of pro-inflammatory cytokines. However, the roles of STRAP in TRIF/TBK1-mediated TLR3 activation and the subsequent type I interferon (IFN) production are not fully elucidated....
Paper Details
Title
STRAP positively regulates TLR3-triggered signaling pathway
Published Date
Aug 1, 2017
Journal
Volume
318
Pages
55 - 60
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