Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
Abstract
Deregulated signal transduction and energy metabolism are hallmarks of cancer and both play a fundamental role in tumorigenesis. While it is increasingly recognised that signalling and metabolism are highly interconnected, the underpinning mechanisms of their co-regulation are still largely unknown. Here we designed and acquired proteomics, phosphoproteomics, and metabolomics experiments in fumarate hydratase (FH) deficient cells and developed a...
Paper Details
Title
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
Published Date
Jan 1, 2018
Journal
Volume
45
Pages
149 - 157
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History