VENETOCLAX (VEN), BENDAMUSTINE (B) AND RITUXIMAB (R) IN PATIENTS (PTS) WITH RELAPSED OR REFRACTORY (R/R) NON-HODGKIN LYMPHOMA (NHL): FINAL RESULTS OF a PHASE I STUDY

Introduction: VEN is a potent, selective BCL-2 inhibitor with clinical activity in R/R NHL pts. Preclinical data suggest synergy between VEN and both B and R; together BR is one of the most commonly used regimens in NHL. Final results of a dose finding study of VEN + BR (NCT01594229) are reported. Methods: This was a Phase 1 dose finding study of VEN + BR in pts ≥18 years with R/R NHL and ECOG PS of 0–1. Diffuse large B-cell lymphoma (DLBCL) pts...