Amyloid β–associated cognitive decline in the absence of clinical disease progression and systemic illness

Introduction High levels of amyloid β (Aβ) are associated with cognitive decline in cognitively normal (CN) older adults. This study investigated the nature of cognitive decline in healthy individuals who did not progress to mild cognitive impairment or dementia. Method Cognition was measured over 72 months and compared between low (Aβ−) and high (Aβ+) CN older adults ( n = 335) who did not progress to mild cognitive impairment or dementia and...