Role of recombination and replication fork restart in repeat instability
Abstract
Eukaryotic genomes contain many repetitive DNA sequences that exhibit size instability. Some repeat elements have the added complication of being able to form secondary structures, such as hairpin loops, slipped DNA, triplex DNA or G-quadruplexes. Especially when repeat sequences are long, these DNA structures can form a significant impediment to DNA replication and repair, leading to DNA nicks, gaps, and breaks. In turn, repair or replication...
Paper Details
Title
Role of recombination and replication fork restart in repeat instability
Published Date
Aug 1, 2017
Journal
Volume
56
Pages
156 - 165
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