Type I Interferon in Chronic Virus Infection and Cancer

IFN-Is drive multiple feedforward and feedback mechanisms promoting inflammatory immunity in a regulated fashion. However, in response to chronic exposure, these regulatory mechanisms may predominate and suppress immunity, thereby promoting pathogen or tumor persistence. In viral infection, IFN-Is are induced, often at high levels, by multiple pattern or damage recognition receptors. In cancer, IFN-Is are likely induced by a more restricted set...