Differential analysis of RNA-seq incorporating quantification uncertainty.
Abstract
We describe sleuth (http://pachterlab.github.io/sleuth), a method for the differential analysis of gene expression data that utilizes bootstrapping in conjunction with response error linear modeling to decouple biological variance from inferential variance. sleuth is implemented in an interactive shiny app that utilizes kallisto quantifications and bootstraps for fast and accurate analysis of data from RNA-seq...
Paper Details
Title
Differential analysis of RNA-seq incorporating quantification uncertainty.
Published Date
Jun 5, 2017
Journal
Volume
14
Issue
7
Pages
687 - 690
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