Therapeutic T cell engineering
Abstract
Genetically engineered T cells are powerful new medicines, offering hope for curative responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of synthetic receptors that reprogram lymphocyte specificity and function. CARs targeting CD19 have demonstrated remarkable potency in B cell malignancies. Engineered T cells are applicable in principle to many cancers, pending further progress to identify suitable target...
Paper Details
Title
Therapeutic T cell engineering
Published Date
May 25, 2017
Journal
Volume
545
Issue
7655
Pages
423 - 431
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Notes
History