Propagation of Tau Aggregates and Neurodegeneration.
Abstract
A pathway from the natively unfolded microtubule-associated protein Tau to a highly structured amyloid fibril underlies human Tauopathies. This ordered assembly causes disease and represents the gain of toxic function. In recent years, evidence has accumulated to suggest that Tau inclusions form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagation of pathology...
Paper Details
Title
Propagation of Tau Aggregates and Neurodegeneration.
Published Date
Aug 3, 2017
Volume
40
Issue
1
Pages
189 - 210
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Notes
History