A Chemogenomic Screening Platform Used to Identify Chemotypes Perturbing HSP90 Pathways
Abstract
Compounds that modulate the heat shock protein (HSP) network have potential in a broad range of research applications and diseases. A yeast-based liquid culture assay that measured time-dependent turbidity enabled the high-throughput screening of different Saccharomyces cerevisae strains to identify HSP modulators with unique molecular mechanisms. A focused set of four strains, with differing sensitivities to Hsp90 inhibitors, was used to screen...
Paper Details
Title
A Chemogenomic Screening Platform Used to Identify Chemotypes Perturbing HSP90 Pathways
Published Date
Jul 1, 2017
Journal
Volume
22
Issue
6
Pages
706 - 719
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