pH triggered controlled drug delivery from contact lenses: Addressing the challenges of drug leaching during sterilization and storage
Abstract
In the present work a novel cyclosporine-loaded Eudragit S100 (pH-sensitive) nanoparticles-laden contact lenses were designed to provide sustained release of cyclosporine at therapeutic rates, without leaching of drug during sterilization and storage period (shelf life). The nanoparticles were prepared by Quasi-emulsion solvent diffusion technique using different weight ratios of cyclosporine to Eudragit S100. The contact lenses with direct drug...
Paper Details
Title
pH triggered controlled drug delivery from contact lenses: Addressing the challenges of drug leaching during sterilization and storage
Published Date
Sep 1, 2017
Volume
157
Pages
72 - 82
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