Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype

Published on Dec 1, 2017in Scientific Reports4.01
· DOI :10.1038/s41598-017-02761-6
W. A. da Silveira1
Estimated H-index: 1
(USP: University of São Paulo),
Patricia Vianna Bonini Palma7
Estimated H-index: 7
(NIST: National Institute of Standards and Technology)
+ 10 AuthorsDaniel Guimarães Tiezzi16
Estimated H-index: 16
(USP: University of São Paulo)
Breast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC) are thought to be responsible for metastasis and chemoresistance. In this study, based on whole transcriptome analysis from putative bCSC and reverse engineering of transcription control networks, we identified two networks associated with this phenotype. One controlled by SNAI2, TWIST1, BNC2, PRRX1 and TBX5 drives a mesenchymal or CSC-like phenotype. The second network is controlled by the SCML4, ZNF831, SP140 and IKZF3 transcription factors which correspond to immune response modulators. Immune response network expression is correlated with pathological response to chemotherapy, and in the Basal subtype is related to better recurrence-free survival. In patient-derived xenografts, the expression of these networks in patient tumours is predictive of engraftment success. Our findings point out a potential molecular mechanism underlying the balance between immune surveillance and EMT activation in breast cancer. This molecular mechanism may be useful to the development of new target therapies.
  • References (61)
  • Citations (5)
#1Ryo Sato (Keio: Keio University)H-Index: 5
#2Takashi Semba (Keio: Keio University)H-Index: 3
Last.Yoshimi Arima (Keio: Keio University)H-Index: 19
view all 4 authors...
42 CitationsSource
#1Ryo Sato (Kumamoto University)H-Index: 5
#2Takashi Semba (Kumamoto University)H-Index: 3
Last.Yoshimi Arima (Keio: Keio University)H-Index: 19
view all 4 authors...
35 CitationsSource
#1Naveen SharmaH-Index: 2
#2Ajay Suresh AkhadeH-Index: 3
Last.Ayub QadriH-Index: 11
view all 3 authors...
9 CitationsSource
#1Rama SoundararajanH-Index: 15
#2Anurag N. ParanjapeH-Index: 10
Last.Sendurai A. ManiH-Index: 38
view all 5 authors...
17 CitationsSource
#1Abdullah AlsulimanH-Index: 1
#2Dilek ColakH-Index: 27
Last.Hazem GhebehH-Index: 17
view all 8 authors...
66 CitationsSource
#1Shengzhe ZhangH-Index: 6
#2Ying JingH-Index: 7
Last.Guanglei ZhuangH-Index: 21
view all 9 authors...
19 CitationsSource
#1Jochen A. Ackermann (NIMR: National Institute for Medical Research)H-Index: 1
#2Josquin Nys (NIMR: National Institute for Medical Research)H-Index: 3
Last.Victor L. J. Tybulewicz (NIMR: National Institute for Medical Research)H-Index: 73
view all 6 authors...
18 CitationsSource
#1Lindsey A. Torre (ACS: American Cancer Society)H-Index: 13
#2Freddie Ian Bray (IARC: International Agency for Research on Cancer)H-Index: 88
Last.Ahmedin Jemal (ACS: American Cancer Society)H-Index: 106
view all 6 authors...
10.9k CitationsSource
#1Ondřej Kodet (Charles University in Prague)H-Index: 6
#2Lukáš Lacina (Charles University in Prague)H-Index: 15
Last.Karel Smetana (Charles University in Prague)H-Index: 34
view all 12 authors...
132 CitationsSource
#1Ming Luo (UM: University of Michigan)H-Index: 23
#2Shawn G. Clouthier (UM: University of Michigan)H-Index: 27
Last.Max S. Wicha (UM: University of Michigan)H-Index: 74
view all 7 authors...
30 CitationsSource
Cited By5
#1Katherine A. Pillman (Institute of Medical and Veterinary Science)H-Index: 10
#2Kaitlin G. Scheer (UniSA: University of South Australia)H-Index: 2
Last.Cameron P. Bracken (University of Adelaide)H-Index: 23
view all 16 authors...
1 CitationsSource
#1Zhuo-Xian Rong (CSU: Central South University)H-Index: 1
#2Zhi Li (CSU: Central South University)H-Index: 8
Last.Lunquan Sun (CSU: Central South University)H-Index: 14
view all 14 authors...
#1Stephan Marquardt (University of Rostock)H-Index: 5
#2Manish Solanki (University of Rostock)H-Index: 2
Last.Brigitte M. Pützer (University of Rostock)H-Index: 36
view all 5 authors...
11 CitationsSource
#1Weiling Zhao (STU: Shantou University)H-Index: 1
#2Zhixue Yu (STU: Shantou University)H-Index: 1
Last.Yueling Zhang (STU: Shantou University)H-Index: 18
view all 8 authors...
1 CitationsSource
#1Mohammad Sultan (Dal: Dalhousie University)H-Index: 6
#2Dejan Vidovic (Dal: Dalhousie University)H-Index: 3
Last.Paola Marcato (Dal: Dalhousie University)H-Index: 21
view all 14 authors...
8 CitationsSource
View next paperAn integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation