Predicting Domain-Specific Health-Related Quality of Life Using Acute Infarct Volume

Published on Jul 1, 2017in Stroke6.058
· DOI :10.1161/STROKEAHA.117.017094
Chen Lin4
Estimated H-index: 4
(NU: Northwestern University),
Jungwha Lee23
Estimated H-index: 23
+ 4 AuthorsShyam Prabhakaran32
Estimated H-index: 32
Background and Purpose— Limited data exist on the relationship between acute infarct volume and health-related quality of life (HRQOL) measures after ischemic stroke. We evaluated whether acute infarct volume predicts domain-specific Neuro-Quality of Life scores at 3 months after stroke. Methods— Between 2012 and 2014, we prospectively enrolled consecutive patients with ischemic stroke and calculated infarct volume. Outcome scores at 3 months included modified Rankin Scale and Neuro-Quality of Life T scores. We evaluated whether volume organized by quartiles predicted modified Rankin Scale and HRQOL scores at 3 months using logistic and linear regression as appropriate, adjusting for relevant covariates. We calculated variance accounted for ( R 2 ) overall and by volume for each domain of HRQOL. Results— Among 490 patients (mean age 64.2±15.86 years; 51.2% male; 63.3% White) included for analysis, 58 (11.8%) were disabled (modified Rankin Scale score of >2) at 3 months. In unadjusted analysis, the highest volume quartile remained a significant predictor of 1 HRQOL domain, applied cognition–general concerns ( R 2 =0.06; P R 2 =0.32), lower extremity ( R 2 =0.51), executive function ( R 2 =0.45), and general concerns ( R 2 =0.34). Conclusions— Acute infarct volume is a poor predictor of HRQOL domains after ischemic stroke, with the exception of the cognitive domain. Overall, clinical and imaging variables explained
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