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Predicting Domain-Specific Health-Related Quality of Life Using Acute Infarct Volume

Published on Jul 1, 2017in Stroke6.058
· DOI :10.1161/STROKEAHA.117.017094
Chen Lin4
Estimated H-index: 4
(NU: Northwestern University),
Jungwha Lee23
Estimated H-index: 23
+ 4 AuthorsShyam Prabhakaran32
Estimated H-index: 32
Abstract
Background and Purpose— Limited data exist on the relationship between acute infarct volume and health-related quality of life (HRQOL) measures after ischemic stroke. We evaluated whether acute infarct volume predicts domain-specific Neuro-Quality of Life scores at 3 months after stroke. Methods— Between 2012 and 2014, we prospectively enrolled consecutive patients with ischemic stroke and calculated infarct volume. Outcome scores at 3 months included modified Rankin Scale and Neuro-Quality of Life T scores. We evaluated whether volume organized by quartiles predicted modified Rankin Scale and HRQOL scores at 3 months using logistic and linear regression as appropriate, adjusting for relevant covariates. We calculated variance accounted for ( R 2 ) overall and by volume for each domain of HRQOL. Results— Among 490 patients (mean age 64.2±15.86 years; 51.2% male; 63.3% White) included for analysis, 58 (11.8%) were disabled (modified Rankin Scale score of >2) at 3 months. In unadjusted analysis, the highest volume quartile remained a significant predictor of 1 HRQOL domain, applied cognition–general concerns ( R 2 =0.06; P R 2 =0.32), lower extremity ( R 2 =0.51), executive function ( R 2 =0.45), and general concerns ( R 2 =0.34). Conclusions— Acute infarct volume is a poor predictor of HRQOL domains after ischemic stroke, with the exception of the cognitive domain. Overall, clinical and imaging variables explained
  • References (25)
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References25
Newest
#1Bradley S. Marino (Children's Memorial Hospital)H-Index: 39
#2Amy Cassedy (Cincinnati Children's Hospital Medical Center)H-Index: 20
Last. Jo Wray (Great Ormond Street Hospital for Children NHS Foundation Trust)H-Index: 28
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In this Review, Daniel Mark examines the use of health-related quality of life (QOL) as an outcome measure in clinical cardiovascular research. The main concepts, assumptions, tools, and methods used to assess QOL are discussed. Applied research into QOL outcomes in coronary artery disease, heart failure, and atrial fibrillation are also summarized, with an emphasis on experience from large, randomized clinical trials.
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#1Rajbeer Singh Sangha (NU: Northwestern University)H-Index: 6
#2Fan Z. Caprio (NU: Northwestern University)H-Index: 6
Last. Shyam Prabhakaran (NU: Northwestern University)H-Index: 32
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#1Aaron D. Boes (Harvard University)H-Index: 13
#2Sashank Prasad (Brigham and Women's Hospital)H-Index: 15
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A traditional and widely used approach for linking neurological symptoms to specific brain regions involves identifying overlap in lesion location across patients with similar symptoms, termed lesion mapping. This approach is powerful and broadly applicable, but has limitations when symptoms do not localize to a single region or stem from dysfunction in regions connected to the lesion site rather than the site itself. A newer approach sensitive to such network effects involves functional neuroim...
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#1Jill Campbell Stewart (UCI: University of California, Irvine)H-Index: 12
#2Steven C. Cramer (UCI: University of California, Irvine)H-Index: 69
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#1David Cella (NU: Northwestern University)H-Index: 134
#2Jin Shei Lai (NU: Northwestern University)H-Index: 46
Last. Claudia S. Moy (NIH: National Institutes of Health)H-Index: 32
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Objective: To address the need for brief, reliable, valid, and standardized quality of life (QOL) assessment applicable across neurologic conditions. Methods: Drawing from larger calibrated item banks, we developed short measures (8–9 items each) of 13 different QOL domains across physical, mental, and social health and evaluated their validity and reliability. Three samples were utilized during short form development: general population (Internet-based, n = 2,113); clinical panel (Internet-base...
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Newest
#1Chen Lin (UAB: University of Alabama at Birmingham)H-Index: 4
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#1Ravi Garg (NU: Northwestern University)H-Index: 3
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#1Chen Lin (UAB: University of Alabama at Birmingham)H-Index: 4
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Purpose In acute ischemic stroke, infarct location and volume have, separately, been used to determine long-term outcomes after stroke. Little information exists on the combination of these imaging characteristics on rehabilitation outcomes. We evaluated the association between infarct lesion location volume with the Functional Independence Measure (FIM) measure during inpatient rehabilitation facility (IRF) in ischemic stroke patients.
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#1Muhib Khan (MSU: Michigan State University)H-Index: 10
#2Heather Heiser (Rush University)H-Index: 1
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#1Chen Lin (UAB: University of Alabama at Birmingham)H-Index: 4
#2Mansi Katkar (RFUMS: Rosalind Franklin University of Medicine and Science)H-Index: 1
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Abstract Objective To evaluate the association between functional measures at admission to acute inpatient rehabilitation (AIR) and health-related quality of life (HRQOL) scores at 3 months after ischemic stroke. Design Consecutive patients with ischemic stroke admitted to AIR were consented to a prospective registry. Setting Large academic referral inpatient rehabilitation hospital. Participants Patients (N=113) with ischemic stroke (mean age 70.6 ± 14.5y; 54.0% male; 56.6% white) were included...
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#1Zhong-Ping Chen (JLU: Jilin University)H-Index: 1
#2Ming-Chao Shi (JLU: Jilin University)
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BackgroundIn patients with mild ischemic stroke, small but eloquent infarcts may have devastating effects, particularly on health-related quality of life.AimThis study investigates the association ...
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