Effect of iron on cholesterol 7α-hydroxylase expression in alcohol-induced hepatic steatosis in mice.

Volume: 58, Issue: 8, Pages: 1548 - 1560
Published: May 23, 2017
Abstract
Both iron and lipids are involved in the progression of alcoholic fatty liver disease (AFLD), but the interaction between iron and lipids in AFLD is unclear. Here, we tested the hypothesis that iron regulates the expression of genes involved in lipid metabolism through iron regulatory proteins (IRPs), which interact with the iron-responsive elements (IREs) in the untranslated regions (UTRs) of genes, resulting in lipid accumulation. Using RNA...
Paper Details
Title
Effect of iron on cholesterol 7α-hydroxylase expression in alcohol-induced hepatic steatosis in mice.
Published Date
May 23, 2017
Volume
58
Issue
8
Pages
1548 - 1560
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