Keap1 knockdown in melanocytes induces cell proliferation and survival via HO-1-associated β-catenin signaling

Background Nrf2-Keap1 signaling pathway protects cells against photo-oxidative stress. Yet in recent works, its role in melanogenesis together with cell protection functions against oxidative stress has been gaining interest. However, its effect on melanogenesis still has contradictory results from different studies. Objective The aims of our study were to investigate the effect of Keap1 silencing in melanocyte on melanogenesis and its...