Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease
Abstract
Tumor necrosis factor alpha (TNF-α) driven processes are involved at multiple stages of Alzheimer's disease (AD) pathophysiology and disease progression. Biologic TNF-α inhibitors (TNFIs) are the most potent class of TNFIs but cannot be developed for AD since these macromolecules do not cross the blood-brain barrier (BBB). A BBB-penetrating TNFI was engineered by the fusion of the extracellular domain of the type II human TNF receptor (TNFR) to...
Paper Details
Title
Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease
Published Date
May 31, 2017
Journal
Volume
14
Issue
7
Pages
2340 - 2349
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Notes
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