Non-homologous DNA end joining and alternative pathways to double-strand break repair.

Volume: 18, Issue: 8, Pages: 495 - 506
Published: May 17, 2017
Abstract
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous DNA end joining (NHEJ) pathway. Defects in NHEJ result in sensitivity to ionizing radiation and the ablation of lymphocytes. The NHEJ pathway utilizes proteins that recognize, resect, polymerize...
Paper Details
Title
Non-homologous DNA end joining and alternative pathways to double-strand break repair.
Published Date
May 17, 2017
Volume
18
Issue
8
Pages
495 - 506
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