Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome
Abstract
The loss of skeletal muscle mass and strength are a central feature of traumatic injury and degenerative myopathies. Unfortunately, pharmacological interventions typically fail to stem the long-term decline in quality of life. Reduced Rev-Erb-mediated gene suppression in cultured C2C12 myoblasts has been shown to stimulate myoblast differentiation. Yet the mechanisms that allow Rev-Erb to pleiotropically inhibit muscle differentiation are not...
Paper Details
Title
Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome
Published Date
Jul 1, 2017
Journal
Volume
6
Issue
7
Pages
703 - 714
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