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Anti-pseudomonal and anti-endotoxic effects of surfactin-stabilized biogenic silver nanocubes ameliorated wound repair in streptozotocin-induced diabetic mice
Published on Apr 3, 2018in Artificial Cells Nanomedicine and Biotechnology 3.03
· DOI :10.1080/21691401.2017.1324461
Natarajan Krishnan1
Estimated H-index: 1
(Bharathidasan University),
Balasubramanian Velramar1
Estimated H-index: 1
(Bharathidasan University)
+ 1 AuthorsRajesh Kannan Velu2
Estimated H-index: 2
(Bharathidasan University)
Abstract
AbstractPseudomonas aeruginosa and its lipopolysaccharides play a key role in the pathogenesis of diabetic foot infection, for which, currently no effective therapeutic agents are available. Hence, newer forms of therapeutic agents are required for treating Pseudomonas aeruginosa infection. In this present study, nanocrystalline silver nanoparticles (AgNPs) were synthesized using culture filtrate of Brevibacillus brevis KN8(2) followed by an investigation of its in vivo anti-pseudomonal and anti-endotoxic properties. Biosynthesized AgNPs was predominantly cubical in shape with an average particle size of 15.40 nm as observed through field emission scanning electron microscopy (FESEM) and X-ray diffraction analysis. The LC-ESI-MS/MS analysis indicates the presence of surfactin in culture filtrate of B. brevis KN8(2). The MIC of surfactin-stabilized AgNPs against P. aeruginosa was 10 μg ml−1 and its wound repair activity was observed in P. aeruginosa-infected wounds of diabetic mice by measuring wound area ...
  • References (35)
  • Cited By (4)
Cite
References35
Published on Jan 1, 2014in Acta Chirurgica Belgica 0.42
Karim Gariani14
Estimated H-index: 14
,
Ilker Uckay28
Estimated H-index: 28
(Geneva College),
Benjamin A. Lipsky68
Estimated H-index: 68
(University of Oxford)
AbstractFoot infections are amongst the most frequent and severe complications linked to diabetes mellitus and are the most common non-traumatic cause of lower limb amputation. Appropriate management of these infections, however, can improve their outcome. The Infectious Diseases Society of America (IDSA) constituted a panel of multidisciplinary experts in 2004 to develop guidelines for the diagnosis and treatment of diabetic foot infections, which have been widely used and validated. Because th...
15 Citations Source Cite
Published on Nov 1, 2007in FEBS Journal 4.53
Wilfried Veron7
Estimated H-index: 7
(University of Rouen),
Olivier Lesouhaitier17
Estimated H-index: 17
(University of Rouen)
+ 4 AuthorsMarc Feuilloley27
Estimated H-index: 27
(University of Rouen)
Natriuretic peptides of various forms are present in animals and plants, and display structural similarities to cyclic antibacterial peptides. Pretreatment of Pseudomonas aeruginosa PAO1 with brain natriuretic peptide (BNP) or C-type natriuretic peptide (CNP) increases bacterium-induced glial cell necrosis. In eukaryotes, natriuretic peptides act through receptors coupled to cyclases. We observed that stable analogs of cAMP (dibutyryl cAMP) and cGMP (8-bromo-cGMP) mimicked the effect of brain na...
22 Citations Source Cite
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Heiko Schuster12
Estimated H-index: 12
(University of Tübingen)
+ 1 AuthorsStefan Beckert16
Estimated H-index: 16
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Jul 6, 2009in ChemMedChem 3.01
Kenneth K. Y. Wong32
Estimated H-index: 32
(University of Hong Kong),
Stephanie O. F. Cheung1
Estimated H-index: 1
(University of Hong Kong)
+ 5 AuthorsPaul Kwong Hang Tam47
Estimated H-index: 47
(University of Hong Kong)
The production of pure silver in nanoparticle size has opened new dimensions in the clinical use of this precious metal. We and others have demonstrated previously that silver nanoparticles (nAg) possess efficient antimicrobial activity. Herein we show they may also have significant anti-inflammatory effects in a postoperative peritoneal adhesion model. This finding provides further insight into the biological actions of nAg as well as a potentially novel therapy for peritoneal adhesions in clin...
115 Citations Source Cite
Hassan Korbekandi9
Estimated H-index: 9
(Isfahan University of Medical Sciences),
Siavash Iravani9
Estimated H-index: 9
(Isfahan University of Medical Sciences),
Sajjad Abbasi3
Estimated H-index: 3
(Isfahan University of Medical Sciences)
BACKGROUND: The objectives of this study were optimization of silver nanoparticle synthesis using biotransformations by Lactobacillus casei subsp. casei, and studying the location of nanoparticles synthesis in this microorganism. RESULTS: The presence of AgNO3 (0.1 mmol L−1) in the culture as the enzyme inducer, and glucose (56 mmol L−1) as the electron donor in the reaction mixture had positive effects on nanoparticle production. By gradually increasing the concentration of AgNO3 (as the substr...
46 Citations Source Cite
Published on Jan 1, 2010in Journal of Investigative Dermatology 6.45
Saher Hamed7
Estimated H-index: 7
(Technion – Israel Institute of Technology),
Yehuda Ullmann27
Estimated H-index: 27
(Technion – Israel Institute of Technology)
+ 3 AuthorsLuc Teot3
Estimated H-index: 3
Wound healing in diabetic patients is slower than in healthy individuals. Erythropoietin (EPO) has nonhemopoietic targets in the skin, and systemically administered EPO promotes wound healing in experimental animals. This study investigated the effect of topical EPO treatment on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 38 rats, of which 30 had diabetes. The wounds were then treated topically with a cream that contained either vehicle...
54 Citations Source Cite
Published on Sep 1, 2010in International Journal of Antimicrobial Agents 4.25
Swarna Jaiswal7
Estimated H-index: 7
(Dublin Institute of Technology),
Brendan Duffy14
Estimated H-index: 14
(Dublin Institute of Technology)
+ 2 AuthorsPatrick McHale7
Estimated H-index: 7
(Dublin Institute of Technology)
Silver nanoparticles (AgNPs) were synthesised by reducing silver salts using NaBH4 followed by capping with varying concentrations of -cyclodextrin (-CD) and were physically characterised. Antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was determined by a microtitre well method. The AgNPs were spherical under transmission electron microscopy, whilst dynamic light scattering showed average diameters of capped particles to be smaller (4-7 nm) than...
85 Citations Source Cite
Published on Mar 21, 2013in PLOS ONE 2.77
Mohammad Oves12
Estimated H-index: 12
(Aligarh Muslim University),
Mohammad Saghir Khan30
Estimated H-index: 30
(Aligarh Muslim University)
+ 6 AuthorsAmeer Azam23
Estimated H-index: 23
(Aligarh Muslim University)
Biofabricated metal nanoparticles are generally biocompatible, inexpensive, and ecofriendly, therefore, are used preferably in industries, medical and material science research. Considering the importance of biofabricated materials, we isolated, characterized and identified a novel bacterial strain OS4 of Stenotrophomonas maltophilia (GenBank: {"type":"entrez-nucleotide","attrs":{"text":"JN247637.1","term_id":"341941875","term_text":"JN247637.1"}}JN247637.1). At neutral pH, this Gram negative ba...
48 Citations Source Cite
Published on Oct 1, 2012in Current Diabetes Reports 3.57
Robert V. Intine12
Estimated H-index: 12
(Rosalind Franklin University of Medicine and Science),
Michael P. Sarras12
Estimated H-index: 12
(Rosalind Franklin University of Medicine and Science)
Recent estimates indicate that diabetes mellitus currently affects more than 10 % of the world’s population. Evidence from both the laboratory and large scale clinical trials has revealed that prolonged hyperglycemia induces chronic complications which persist and progress unimpeded even when glycemic control is pharmaceutically achieved via the phenomenon of metabolic memory. The epigenome is comprised of all chromatin modifications including post translational histone modification, expression ...
43 Citations Source Cite
Published on Dec 1, 2010in Canadian Journal of Microbiology 1.24
Kandasamy Kathiresan25
Estimated H-index: 25
,
Nabeel M. Alikunhi6
Estimated H-index: 6
+ 2 AuthorsSaravanakumar KandasamyS. Kandasamy1
Estimated H-index: 1
The present study investigated the extracellular biosynthesis of antimicrobial silver nanoparticles by Escherichia coli AUCAS 112 and Aspergillus niger AUCAS 237 derived from coastal mangrove sediment of southeast India. Both microbial species were able to produce silver nanoparticles, as confirmed by X-ray diffraction spectrum. The nanoparticles synthesized were mostly spherical, ranging in size from 5 to 20 nm for E. coli and from 5 to 35 nm for A. niger, as evident by transmission electron mi...
55 Citations Source Cite
Cited By4
Published on Oct 26, 2017in Frontiers in Pharmacology 3.83
Yuan-Seng Wu1
Estimated H-index: 1
(Monash University Malaysia Campus),
Siew-Ching Ngai1
Estimated H-index: 1
(University of Nottingham Malaysia Campus)
+ 3 AuthorsLay-Hong Chuah7
Estimated H-index: 7
(Monash University Malaysia Campus)
Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types, such as Ehrlich ascites, breast and colon cancers, leukemia and hepatoma. Surfactin treatment can inhibit cancer progression by growth inhibition, cell cycle arrest, apoptosis and metastasis arrest. Owing to the potent effect of surfactin on cancer cells, numerous studies have recently investigated the mechanisms that underlie its anticance...
8 Citations Source Cite
Published on Oct 31, 2018in Artificial Cells Nanomedicine and Biotechnology 3.03
Abdul Ahad11
Estimated H-index: 11
(King Saud University),
Mohammad Raish13
Estimated H-index: 13
(King Saud University)
+ 2 AuthorsAbdullah M. Al-Mohizea12
Estimated H-index: 12
(King Saud University)
1 Citations Source Cite
Published on Oct 1, 2018in Materials Science and Engineering: C 5.08
Natarajan Krishnan1
Estimated H-index: 1
(Bharathidasan University),
Balasubramanian Velramar1
Estimated H-index: 1
(Bharathidasan University)
+ 4 AuthorsRajesh Kannan Velu2
Estimated H-index: 2
(Bharathidasan University)
Source Cite
ABSTRACTCharacterized as one of the most potent biosurfactants, surfactin is a cyclic lipopeptide synthesized by several strains of Bacillus genus. The aim of this review was to present the physicochemical and structural properties of surfactin and to demonstrate advances and applications of this biosurfactant for health and environmental biotechnology. Further, this review also focused on toxicological effects of surfactin on in vivo and in in vitro systems. The hydrophobic nature of surfactin ...
1 Citations Source Cite
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