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Anti-pseudomonal and anti-endotoxic effects of surfactin-stabilized biogenic silver nanocubes ameliorated wound repair in streptozotocin-induced diabetic mice

Published on Apr 3, 2018in Artificial Cells Nanomedicine and Biotechnology 3.03
· DOI :10.1080/21691401.2017.1324461
Natarajan Krishnan1
Estimated H-index: 1
(Bharathidasan University),
Balasubramanian Velramar1
Estimated H-index: 1
(Bharathidasan University)
+ 1 AuthorsRajesh Kannan Velu2
Estimated H-index: 2
(Bharathidasan University)
Abstract
AbstractPseudomonas aeruginosa and its lipopolysaccharides play a key role in the pathogenesis of diabetic foot infection, for which, currently no effective therapeutic agents are available. Hence, newer forms of therapeutic agents are required for treating Pseudomonas aeruginosa infection. In this present study, nanocrystalline silver nanoparticles (AgNPs) were synthesized using culture filtrate of Brevibacillus brevis KN8(2) followed by an investigation of its in vivo anti-pseudomonal and anti-endotoxic properties. Biosynthesized AgNPs was predominantly cubical in shape with an average particle size of 15.40 nm as observed through field emission scanning electron microscopy (FESEM) and X-ray diffraction analysis. The LC-ESI-MS/MS analysis indicates the presence of surfactin in culture filtrate of B. brevis KN8(2). The MIC of surfactin-stabilized AgNPs against P. aeruginosa was 10 μg ml−1 and its wound repair activity was observed in P. aeruginosa-infected wounds of diabetic mice by measuring wound area ...
  • References (35)
  • Citations (5)
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References35
Newest
Published on Feb 1, 2017in Materials Letters 2.69
Subramanian Palanisamy8
Estimated H-index: 8
(Alagappa University),
Periyannan Rajasekar6
Estimated H-index: 6
(Alagappa University)
+ 3 AuthorsNarayanan Marimuthu Prabhu11
Estimated H-index: 11
(Alagappa University)
Abstract The aim of the present study is to find out a biocompatible silver nanoparticles synthesized from Sargassum polycystum for antioxidant and anticancer activity. The phytochemical constituent was investigated by standard method and it possesses alkaloids, flavanoids, steroids, terpenoids, protein, amino acids, carbohydrate, quinones, phenols and tannins. The synthesized AgNPs were characterized by various spectroscopic and microscopic techniques. Interestingly, AgNPs exhibit highest level...
15 Citations Source Cite
Published on Dec 1, 2016in Microbial Cell Factories 3.83
D. O. Plaza2
Estimated H-index: 2
(Andrés Bello National University),
C. Gallardo2
Estimated H-index: 2
(Andrés Bello National University)
+ 2 AuthorsJosé M. Pérez-Donoso15
Estimated H-index: 15
(Andrés Bello National University)
Background Fluorescent nanoparticles or quantum dots (QDs) have been intensely studied for basic and applied research due to their unique size-dependent properties. There is an increasing interest in developing ecofriendly methods to synthesize these nanoparticles since they improve biocompatibility and avoid the generation of toxic byproducts. The use of biological systems, particularly prokaryotes, has emerged as a promising alternative. Recent studies indicate that QDs biosynthesis is related...
21 Citations Source Cite
Published on Dec 1, 2016in Nanoscale Research Letters 3.13
K. S. Siddiqi20
Estimated H-index: 20
(Aligarh Muslim University),
Azamal Husen19
Estimated H-index: 19
(University of Gondar)
Fungi secrete enzymes and proteins as reducing agents which can be used for the synthesis of metal nanoparticles from metal salts. Large-scale production of nanoparticles from diverse fungal strains has great potential since they can be grown even in vitro. In recent years, various approaches have been made to maximize the yield of nanoparticles of varying shape, size, and stability. They have been characterized by thermogravimetric analysis, X-ray diffractometry, SEM/TEM, zeta potential measure...
50 Citations Source Cite
Published on Feb 1, 2016in Materials Science and Engineering: C 5.08
Chidambaram Kulandaisamy Venil10
Estimated H-index: 10
(Universiti Teknologi Malaysia),
Palanivel Sathishkumar15
Estimated H-index: 15
(Universiti Teknologi Malaysia)
+ 4 AuthorsWan Azlina Ahmad13
Estimated H-index: 13
(Universiti Teknologi Malaysia)
Abstract In this work, the synthesis of silver nanoparticles from a pigment produced by a recently-discovered bacterium, Chryseobacterium artocarpi CECT 8497, was achieved, followed by an investigation of its anticancer properties. The bacterial pigment was identified as flexirubin following NMR ( 1 H NMR and 13 C NMR), UV–Vis, and LC–MS analysis. An aqueous silver nitrate solution was treated with isolated flexirubin to produce silver nanoparticles. The synthesised silver nanoparticles were sub...
20 Citations Source Cite
Published on Jan 1, 2014in Infection and Immunity 3.26
Chase Watters10
Estimated H-index: 10
(Texas Tech University Health Sciences Center),
Jake Everett5
Estimated H-index: 5
(Texas Tech University Health Sciences Center)
+ 2 AuthorsKendra P. Rumbaugh31
Estimated H-index: 31
(Texas Tech University Health Sciences Center)
Diabetes affects 25.8 million people in the United States, or 8.3% of the population, and these numbers are even higher in developing countries. Diabetic patients are more susceptible to the development of chronic wounds with debilitating bacterial infections than nondiabetics. Previously, we compared the ability of the opportunistic pathogen Pseudomonas aeruginosa to cause biofilm-associated infections in chronic wounds of diabetic and nondiabetic mice (C. Watters, K. DeLeon, U. Trivedi, J. A. ...
33 Citations Source Cite
Published on Jan 1, 2014in Acta Chirurgica Belgica 0.42
Karim Gariani15
Estimated H-index: 15
,
Ilker Uckay28
Estimated H-index: 28
(Geneva College),
Benjamin A. Lipsky69
Estimated H-index: 69
(University of Oxford)
AbstractFoot infections are amongst the most frequent and severe complications linked to diabetes mellitus and are the most common non-traumatic cause of lower limb amputation. Appropriate management of these infections, however, can improve their outcome. The Infectious Diseases Society of America (IDSA) constituted a panel of multidisciplinary experts in 2004 to develop guidelines for the diagnosis and treatment of diabetic foot infections, which have been widely used and validated. Because th...
15 Citations Source Cite
Markus Loeffler77
Estimated H-index: 77
(University of Tübingen),
Heiko Schuster13
Estimated H-index: 13
(University of Tübingen)
+ 1 AuthorsStefan Beckert17
Estimated H-index: 17
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Apr 1, 2013in Medical Microbiology and Immunology 3.20
Chase Watters10
Estimated H-index: 10
(Texas Tech University Health Sciences Center),
Katrina DeLeon2
Estimated H-index: 2
(Texas Tech University Health Sciences Center)
+ 5 AuthorsKendra P. Rumbaugh31
Estimated H-index: 31
(Texas Tech University Health Sciences Center)
Diabetic patients are more susceptible to the development of chronic wounds than non-diabetics. The impaired healing properties of these wounds, which often develop debilitating bacterial infections, significantly increase the rate of lower extremity amputation in diabetic patients. We hypothesize that bacterial biofilms, or sessile communities of bacteria that reside in a complex matrix of exopolymeric material, contribute to the severity of diabetic wounds. To test this hypothesis, we develope...
60 Citations Source Cite
Published on Mar 21, 2013in PLOS ONE 2.77
Mohammad Oves21
Estimated H-index: 21
(Aligarh Muslim University),
Mohammad Saghir Khan30
Estimated H-index: 30
(Aligarh Muslim University)
+ 6 AuthorsAmeer Azam24
Estimated H-index: 24
(Aligarh Muslim University)
Biofabricated metal nanoparticles are generally biocompatible, inexpensive, and ecofriendly, therefore, are used preferably in industries, medical and material science research. Considering the importance of biofabricated materials, we isolated, characterized and identified a novel bacterial strain OS4 of Stenotrophomonas maltophilia (GenBank: {"type":"entrez-nucleotide","attrs":{"text":"JN247637.1","term_id":"341941875","term_text":"JN247637.1"}}JN247637.1). At neutral pH, this Gram negative ba...
55 Citations Source Cite
Published on Feb 1, 2013in Infection 2.77
N.C. Schaper1
Estimated H-index: 1
(Maastricht University),
M. Dryden12
Estimated H-index: 12
(Royal Hampshire County Hospital)
+ 5 AuthorsInge C. Gyssens27
Estimated H-index: 27
(University of Hasselt)
Objective The aim was to compare the efficacy and safety of two antibiotic regimens in patients with diabetic foot infections (DFIs).
29 Citations Source Cite
Cited By5
Newest
Published on Mar 1, 2019in Pesticide Biochemistry and Physiology 3.44
Natarajan Krishnan1
Estimated H-index: 1
(Bharathidasan University),
Balasubramanian Velramar1
Estimated H-index: 1
(Bharathidasan University),
Rajesh Kannan Velu2
Estimated H-index: 2
(Bharathidasan University)
Abstract The mycotoxigenic phytopathogenic fungus such as Fusarium moniliforme contamination in maize kernels may not only affect seed germination but also negatively cause mycotoxicosis in animals and humans. There is no effective fungicides to control the growth of F. moniliforme on maize kernels. Hence, effective bioactive compounds are needed to prevent plant and animal diseases associated with F. moniliforme contamination in cereals. Surfactin is an well-known antimicrobial lipopeptide has ...
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Vanessa Santana Vieira Santos3
Estimated H-index: 3
,
Edgar Silveira1
Estimated H-index: 1
,
Boscolli Barbosa Pereira7
Estimated H-index: 7
ABSTRACTCharacterized as one of the most potent biosurfactants, surfactin is a cyclic lipopeptide synthesized by several strains of Bacillus genus. The aim of this review was to present the physicochemical and structural properties of surfactin and to demonstrate advances and applications of this biosurfactant for health and environmental biotechnology. Further, this review also focused on toxicological effects of surfactin on in vivo and in in vitro systems. The hydrophobic nature of surfactin ...
1 Citations Source Cite
Published on Oct 31, 2018in Artificial Cells Nanomedicine and Biotechnology 3.03
Abdul Ahad19
Estimated H-index: 19
(King Saud University),
Mohammad Raish14
Estimated H-index: 14
(King Saud University)
+ 2 AuthorsAbdullah M. Al-Mohizea13
Estimated H-index: 13
(King Saud University)
1 Citations Source Cite
Published on Oct 1, 2018in Materials Science and Engineering: C 5.08
Natarajan Krishnan1
Estimated H-index: 1
(Bharathidasan University),
Balasubramanian Velramar1
Estimated H-index: 1
(Bharathidasan University)
+ 4 AuthorsRajesh Kannan Velu2
Estimated H-index: 2
(Bharathidasan University)
Abstract Microbial contamination along with over expressions of matrix metalloproteinases 2 and 9 impairs wound healing in diabetic patients. Silver-based antimicrobial agents have been successfully used for treating non-healing chronic wounds associated with infection. However, topical application of silver-ion compounds impairs wound healing process. Thus, usage of biogenic silver nanoparticles appears as a new means to reduce the toxicity of silver compounds in the wound care system. Here, fo...
1 Citations Source Cite
Published on Oct 26, 2017in Frontiers in Pharmacology 3.83
Yuan-Seng Wu1
Estimated H-index: 1
(Monash University Malaysia Campus),
Siew-Ching Ngai1
Estimated H-index: 1
(University of Nottingham Malaysia Campus)
+ 3 AuthorsLay-Hong Chuah8
Estimated H-index: 8
(Monash University Malaysia Campus)
Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types, such as Ehrlich ascites, breast and colon cancers, leukemia and hepatoma. Surfactin treatment can inhibit cancer progression by growth inhibition, cell cycle arrest, apoptosis and metastasis arrest. Owing to the potent effect of surfactin on cancer cells, numerous studies have recently investigated the mechanisms that underlie its anticance...
14 Citations Source Cite