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Development and Translation of PEDOT:PSS Microelectrodes for Intraoperative Monitoring

Published on Mar 1, 2018in Advanced Functional Materials 15.62
· DOI :10.1002/adfm.201700232
Mehran Ganji3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Erik Kaestner5
Estimated H-index: 5
(UCSD: University of California, San Diego)
+ 15 AuthorsShadi A. Dayeh31
Estimated H-index: 31
(UCSD: University of California, San Diego)
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Abstract
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based interfaces surpass those of current clinical electrocorticography electrodes. Here, robust fabrication process of PEDOT:PSS microelectrode arrays is demonstrated for safe and high fidelity intraoperative monitoring of human brain. PEDOT:PSS microelectrodes measure significant differential neural modulation under various clinically relevant conditions. This study reports the first evoked (stimulus-locked) cognitive activity with changes in amplitude across pial surface distances as small as 400 µm, potentially enabling basic neurophysiology studies at the scale of neural micro-circuitry.
  • References (55)
  • Citations (10)
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References55
Newest
Published on Dec 1, 2016in Advanced Healthcare Materials 6.27
Ilke Uguz9
Estimated H-index: 9
('ENS Paris': École Normale Supérieure),
Mehran Ganji3
Estimated H-index: 3
(UCSD: University of California, San Diego)
+ 9 AuthorsChristophe Bernard37
Estimated H-index: 37
(AMU: Aix-Marseille University)
Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on the devices. This finding paves the way to widespread introduction of PEDOT:PSS electrophysiology devices to the clinic.
Published on Nov 24, 2016in The New England Journal of Medicine 70.67
Mariska J. Vansteensel20
Estimated H-index: 20
,
Elmar Pels2
Estimated H-index: 2
+ 10 AuthorsMax van den Boom1
Estimated H-index: 1
Options for people with severe paralysis who have lost the ability to communicate orally are limited. We describe a method for communication in a patient with late-stage amyotrophic lateral sclerosis (ALS), involving a fully implanted brain–computer interface that consists of subdural electrodes placed over the motor cortex and a transmitter placed subcutaneously in the left side of the thorax. By attempting to move the hand on the side opposite the implanted electrodes, the patient accurately a...
Published on Nov 1, 2016in Science Advances
Dion Khodagholy17
Estimated H-index: 17
(NYU: New York University),
Jennifer N. Gelinas13
Estimated H-index: 13
(NYU: New York University)
+ 6 AuthorsGyörgy Buzsáki124
Estimated H-index: 124
(NYU: New York University)
Localizing neuronal patterns that generate pathological brain signals may assist with tissue resection and intervention strategies in patients with neurological diseases. Precise localization requires high spatiotemporal recording from populations of neurons while minimizing invasiveness and adverse events. We describe a large-scale, high-density, organic material–based, conformable neural interface device (“NeuroGrid”) capable of simultaneously recording local field potentials (LFPs) and action...
Published on Sep 1, 2016in Nature Communications 11.88
Jonathan Rivnay36
Estimated H-index: 36
(ENSMP: Mines ParisTech),
Sahika Inal18
Estimated H-index: 18
(ENSMP: Mines ParisTech)
+ 6 AuthorsGeorge G. Malliaras69
Estimated H-index: 69
(ENSMP: Mines ParisTech)
Conducting polymers are promising materials for applications including bioelectronics and soft robotics, but little is known about how morphology affects mixed conduction. Here, the authors show how bulk ionic/electronic transport is affected by changes in nano- and meso-scale structure in PEDOT:PSS films.
Published on Jan 20, 2016in Journal of Neural Engineering 4.55
Stuart F. Cogan27
Estimated H-index: 27
(UTD: University of Texas at Dallas),
Kip A. Ludwig11
Estimated H-index: 11
(Mayo Clinic)
+ 1 AuthorsPavel Takmakov18
Estimated H-index: 18
(Silver Spring Networks)
Recent initiatives in bioelectronic modulation of the nervous system by the NIH (SPARC), DARPA (ElectRx, SUBNETS) and the GlaxoSmithKline Bioelectronic Medicines effort are ushering in a new era of therapeutic electrical stimulation. These novel therapies are prompting a re-evaluation of established electrical thresholds for stimulation-induced tissue damage.In this review, we explore what is known and unknown in published literature regarding tissue damage from electrical stimulation.For macroe...
Published on Jan 1, 2016in Clinical Neurophysiology 3.67
Spencer Kellis12
Estimated H-index: 12
(UofU: University of Utah),
Larry B. Sorensen30
Estimated H-index: 30
(UW: University of Washington)
+ 6 AuthorsBradley Greger19
Estimated H-index: 19
(ASU: Arizona State University)
Abstract Objective Electrocorticography grids have been used to study and diagnose neural pathophysiology for over 50years, and recently have been used for various neural prosthetic applications. Here we provide evidence that micro-scale electrodes are better suited for studying cortical pathology and function, and for implementing neural prostheses. Methods This work compares dynamics in space, time, and frequency of cortical field potentials recorded by three types of electrodes: electrocortic...
Published on Jan 1, 2016in Epilepsy and behavior case reports
AmiLyn Taplin3
Estimated H-index: 3
(Albany Medical College),
Adriana de Pesters4
Estimated H-index: 4
(University at Albany, SUNY)
+ 5 AuthorsGerwin Schalk44
Estimated H-index: 44
(University at Albany, SUNY)
In this case report, we investigated the utility and practicality of passive intraoperative functional mapping of expressive language cortex using high-resolution electrocorticography (ECoG). The patient presented here experienced new-onset seizures caused by a medium-grade tumor in very close proximity to expressive language regions. In preparation of tumor resection, the patient underwent multiple functional language mapping procedures. We examined the relationship of results obtained with int...
Published on Feb 1, 2015in Nature Neuroscience 21.13
Dion Khodagholy17
Estimated H-index: 17
,
Jennifer N. Gelinas13
Estimated H-index: 13
+ 4 AuthorsGyörgy Buzsáki124
Estimated H-index: 124
In this technical report, Khodagholy and colleagues find that NeuroGrid, a planar, scalable and highly conformable electrode array, allows recordings of local-field potentials and stable single-unit activity from the surface of the rat cortex or hippocampus. The authors also validate NeuroGrid across species by showing that that it can capture LFP-modulated spiking activity intraoperatively in surgical patients, thus demonstrating its utility as tool for fundamental research on the human brain a...
Published on Feb 28, 2014in Science 41.04
Nima Mesgarani19
Estimated H-index: 19
(UCSF: University of California, San Francisco),
Connie Cheung3
Estimated H-index: 3
(UCSF: University of California, San Francisco)
+ 1 AuthorsEdward F. Chang58
Estimated H-index: 58
(UCSF: University of California, San Francisco)
During speech perception, linguistic elements such as consonants and vowels are extracted from a complex acoustic speech signal. The superior temporal gyrus (STG) participates in high-order auditory processing of speech, but how it encodes phonetic information is poorly understood. We used high-density direct cortical surface recordings in humans while they listened to natural, continuous speech to reveal the STG representation of the entire English phonetic inventory. At single electrodes, we f...
Published on Feb 1, 2014in Journal of Neural Engineering 4.55
David T. Bundy11
Estimated H-index: 11
(WashU: Washington University in St. Louis),
Erik Zellmer3
Estimated H-index: 3
(WashU: Washington University in St. Louis)
+ 7 AuthorsEric C. Leuthardt36
Estimated H-index: 36
Objective. Electrocorticography (ECoG) electrodes implanted on the surface of the brain have recently emerged as a potential signal platform for brain?computer interface (BCI) systems. While clinical ECoG electrodes are currently implanted beneath the dura, epidural electrodes could reduce the invasiveness and the potential impact of a surgical site infection. Subdural electrodes, on the other hand, while slightly more invasive, may have better signals for BCI application. Because of this balanc...
Cited By10
Newest
Published on Jul 19, 2019in Npg Asia Materials 8.05
Youngbin Tchoe7
Estimated H-index: 7
(SNU: Seoul National University),
Kunook Chung8
Estimated H-index: 8
(SNU: Seoul National University)
+ 5 AuthorsGyu-Chul Yi50
Estimated H-index: 50
(SNU: Seoul National University)
We report on the fabrication and characteristics of an individually addressable gallium nitride (GaN) microdisk light-emitting diode (LED) array in free-standing and ultrathin form. A high-quality GaN microdisk array with n-GaN, InGaN/GaN quantum wells and p-GaN layers was epitaxially grown on graphene microdots patterned on SiO2/Si substrates. Due to the weak attachment of the graphene microdots to the growth substrate, a microdisk array coated with a polyimide layer was easily separated from t...
Published in Bioelectromagnetics 1.95
Christian Boehler9
Estimated H-index: 9
(University of Freiburg),
Zaid Aqrawe3
Estimated H-index: 3
(University of Auckland),
Maria Asplund12
Estimated H-index: 12
(University of Freiburg)
Published on Mar 12, 2019in Advanced Materials 25.81
Erica Zeglio (UNSW: University of New South Wales), Alexandra L. Rutz7
Estimated H-index: 7
(University of Cambridge)
+ 2 AuthorsAnna Herland20
Estimated H-index: 20
(KI: Karolinska Institutet)
The field of organic bioelectronics is advancing rapidly in the development of materials and devices to precisely monitor and control biological signals. Electronics and biology can interact on multiple levels: organs, complex tissues, cells, cell membranes, proteins, and even small molecules. Compared to traditional electronic materials such as metals and inorganic semiconductors, conjugated polymers (CPs) have several key advantages for biological interactions: tunable physiochemical propertie...
Published on Apr 1, 2019in Advanced Materials 25.81
Kezhong Wang1
Estimated H-index: 1
(UOW: University of Wollongong),
Christopher L. Frewin12
Estimated H-index: 12
(UTD: University of Texas at Dallas)
+ 6 AuthorsRouhollah Jalili2
Estimated H-index: 2
(UNSW: University of New South Wales)
Published on Feb 11, 2019in PLOS Computational Biology
Nicholas Rogers1
Estimated H-index: 1
(UCSD: University of California, San Diego),
John Hermiz3
Estimated H-index: 3
(UCSD: University of California, San Diego)
+ 11 AuthorsDavid Barba5
Estimated H-index: 5
(UCSD: University of California, San Diego)
Electrocorticography (ECoG) is becoming more prevalent due to improvements in fabrication and recording technology as well as its ease of implantation compared to intracortical electrophysiology, larger cortical coverage, and potential advantages for use in long term chronic implantation. Given the flexibility in the design of ECoG grids, which is only increasing, it remains an open question what geometry of the electrodes is optimal for an application. Conductive polymer, PEDOT:PSS, coated micr...
Published on Feb 1, 2019in Journal of Neural Engineering 4.55
Tejaswy Pailla2
Estimated H-index: 2
(UCSD: University of California, San Diego),
Kai J. Miller39
Estimated H-index: 39
(Stanford University),
Vikash Gilja21
Estimated H-index: 21
(UCSD: University of California, San Diego)
Published on Dec 1, 2018in Advanced Materials 25.81
Chunfeng Wang10
Estimated H-index: 10
(UCSD: University of California, San Diego),
Chonghe Wang4
Estimated H-index: 4
(UCSD: University of California, San Diego)
+ 1 AuthorsSheng Xu35
Estimated H-index: 35
(UCSD: University of California, San Diego)
Published on Nov 1, 2018in Npg Asia Materials 8.05
Youngseok Kim4
Estimated H-index: 4
(Gwangju Institute of Science and Technology),
Taekyung Lim10
Estimated H-index: 10
(KGU: Kyonggi University)
+ 7 AuthorsMyung-Han Yoon14
Estimated H-index: 14
(Gwangju Institute of Science and Technology)
Despite the great potential of polymer microfibers in human-friendly wearable electronics, most previous polymeric electronics have been limited to thin-film-based devices due to practical difficulties in fabricating microfibrillar devices, as well as defining the active channel dimensions in a reproducible manner. Herein, we report on conducting polymer microfiber-based organic electrochemical transistors (OECTs) and their application in single-strand fiber-type wearable ion concentration senso...
Published on Nov 1, 2018in Advanced Healthcare Materials 6.27
Mehran Ganji3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Lorraine Hossain1
Estimated H-index: 1
(UCSD: University of California, San Diego)
+ 5 AuthorsShadi A. Dayeh31
Estimated H-index: 31
(UCSD: University of California, San Diego)
Published on Aug 1, 2018in NeuroImage 5.81
John Hermiz3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Nicholas Rogers1
Estimated H-index: 1
(UCSD: University of California, San Diego)
+ 7 AuthorsVikash Gilja21
Estimated H-index: 21
(UCSD: University of California, San Diego)
Abstract Electrocorticography (ECoG), electrophysiological recording from the pial surface of the brain, is a critical measurement technique for clinical neurophysiology, basic neurophysiology studies, and demonstrates great promise for the development of neural prosthetic devices for assistive applications and the treatment of neurological disorders. Recent advances in device engineering are poised to enable orders of magnitude increase in the resolution of ECoG without comprised measurement qu...