A proteomic-based investigation of potential copper-responsive biomarkers: Proteins, conceptual networks, and metabolic pathways featuringPenicillium janthinellumfrom a heavy metal-polluted ecological niche

Filamentous fungi‐copper (Cu) interactions are very important in the formation of natural ecosystems and the bioremediation of heavy metal pollution. However, important issues at the proteome level remain unclear. We compared six proteomes from Cu‐resistant wild‐type ( WT ) Penicillium janthinellum strain GXCR and a Cu‐sensitive mutant ( EC ‐6) under 0, 0.5, and 3 mmol/L Cu treatments using i TRAQ . A total of 495 known proteins were identified,...