Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation

Volume: 232, Issue: 11, Pages: 3006 - 3019
Published: Jun 14, 2017
Abstract
The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mechanisms are still unknown. Due to the known embryonic lethality induced by global Pdpn deletion, we have herein explored the effect of bone-specific Pdpn knockdown on osteocyte form and function in the post-natal mouse. Extensive skeletal phenotyping of male and female...
Paper Details
Title
Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation
Published Date
Jun 14, 2017
Volume
232
Issue
11
Pages
3006 - 3019
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